- 2021 04 21, 20:37
#414451
Kuris neuroleptikas geriausias?
212 trials containing 43,209 participants were identified, 144 (68%) had been conducted by the pharmaceutical industry.
All drugs included in the analysis fared better than placebo.
There were high rates of withdrawal across all the studies at about 35%.
No one drug was best across all the domains – see summary table of best/worst performers across the domains.
Five atypical anti-psychotics had significantly more EPSE than placebo.
Efficacy (symptom change) – the best performers were Clozapine, Amisulpride & Olanzapine, the worst performers were Asenapine, Lurasidone & Iloperidone.
All cause discontinuation – the best performers were Amisulpride, Olanzapine & Clozapine, the worst performers were Lurasidone, Sertindole & Haloperidol.
EPSE – the best performers were Clozapine, Sertindole & Olanzapine, the worst performers Chlorpromazine, Zotepine & Haloperidol.
Weight gain – the best performers were Haloperidol, Ziprasidone & Lurasidone, the worst performers Clozapine, Zotepine & Olanzapine.
Prolactin increase* – the best performers were Aripiprazole, Quetiapine & Asenapine, the worst performers were Haloperidol, Risperidone & Paliperidone.
QTc prolongation** – the best performers were Lurasidone, Aripirazole & Paliperidone, the worst performers were Ziprasidone, Amisulpride & Sertindole.
Sedation – the best performers were Amisulpride, Paliperidone & Sertindole, the worst performers were Chlorpromazine, Zotepine & Clozapine.
https://www.nationalelfservice.net/ment ... -the-best/
212 trials containing 43,209 participants were identified, 144 (68%) had been conducted by the pharmaceutical industry.
All drugs included in the analysis fared better than placebo.
There were high rates of withdrawal across all the studies at about 35%.
No one drug was best across all the domains – see summary table of best/worst performers across the domains.
Five atypical anti-psychotics had significantly more EPSE than placebo.
Efficacy (symptom change) – the best performers were Clozapine, Amisulpride & Olanzapine, the worst performers were Asenapine, Lurasidone & Iloperidone.
All cause discontinuation – the best performers were Amisulpride, Olanzapine & Clozapine, the worst performers were Lurasidone, Sertindole & Haloperidol.
EPSE – the best performers were Clozapine, Sertindole & Olanzapine, the worst performers Chlorpromazine, Zotepine & Haloperidol.
Weight gain – the best performers were Haloperidol, Ziprasidone & Lurasidone, the worst performers Clozapine, Zotepine & Olanzapine.
Prolactin increase* – the best performers were Aripiprazole, Quetiapine & Asenapine, the worst performers were Haloperidol, Risperidone & Paliperidone.
QTc prolongation** – the best performers were Lurasidone, Aripirazole & Paliperidone, the worst performers were Ziprasidone, Amisulpride & Sertindole.
Sedation – the best performers were Amisulpride, Paliperidone & Sertindole, the worst performers were Chlorpromazine, Zotepine & Clozapine.
https://www.nationalelfservice.net/ment ... -the-best/